Ms-58 Solved Assignment 2012

1. Guo Y., Cordes K. R., Farese R. V. Jr., and Walther T. C. (2009) Lipid droplets at a glance. J. Cell Sci. 122, 749–752 [PMC free article][PubMed]

2. Lass A., Zimmermann R., Haemmerle G., Riederer M., Schoiswohl G., Schweiger M., Kienesberger P., Strauss J. G., Gorkiewicz G., and Zechner R. (2006) Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome. Cell Metab. 3, 309–319 [PubMed]

3. Oberer M., Boeszoermenyi A., Nagy H. M., and Zechner R. (2011) Recent insights into the structure and function of comparative gene identification-58. Curr. Opin. Lipidol. 22, 149–158 [PMC free article][PubMed]

4. Lass A., Zimmermann R., Oberer M., and Zechner R. (2011) Lipolysis: a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores. Prog. Lipid Res. 50, 14–27 [PMC free article][PubMed]

5. Fischer J., Lefèvre C., Morava E., Mussini J. M., Laforêt P., Negre-Salvayre A., Lathrop M., and Salvayre R. (2007) The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy. Nat. Genet. 39, 28–30 [PubMed]

6. Radner F. P., and Fischer J. (2014) The important role of epidermal triacylglycerol metabolism for maintenance of the skin permeability barrier function. Biochim. Biophys. Acta1841, 409–415 [PubMed]

7. Schweiger M., Lass A., Zimmermann R., Eichmann T. O., and Zechner R. (2009) Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase/PNPLA2 or CGI-58/ABHD5. Am. J. Physiol. Endocrinol. Metab. 297, E289–296 [PubMed]

8. Zierler K. A., Zechner R., and Haemmerle G. (2014) Comparative gene identification-58/α/β hydrolase domain 5: more than just an adipose triglyceride lipase activator?Curr. Opin. Lipidol. 25, 102–109 [PMC free article][PubMed]

9. Brasaemle D. L., Levin D. M., Adler-Wailes D. C., and Londos C. (2000) The lipolytic stimulation of 3T3-L1 adipocytes promotes the translocation of hormone-sensitive lipase to the surfaces of lipid storage droplets. Biochim. Biophys. Acta1483, 251–262 [PubMed]

10. Cerk I. K., Salzburger B., Boeszoermenyi A., Heier C., Pillip C., Romauch M., Schweiger M., Cornaciu I., Lass A., Zimmermann R., Zechner R., and Oberer M. (2014) A peptide derived from G0/G1 switch gene 2 acts as noncompetitive inhibitor of adipose triglyceride lipase. J. Biol. Chem. 289, 32559–32570 [PMC free article][PubMed]

11. Chung C., Doll J. A., Gattu A. K., Shugrue C., Cornwell M., Fitchev P., and Crawford S. E. (2008) Anti-angiogenic pigment epithelium-derived factor regulates hepatocyte triglyceride content through adipose triglyceride lipase (ATGL). J. Hepatol. 48, 471–478 [PubMed]

12. Cornaciu I., Boeszoermenyi A., Lindermuth H., Nagy H. M., Cerk I. K., Ebner C., Salzburger B., Gruber A., Schweiger M., Zechner R., Lass A., Zimmermann R., and Oberer M. (2011) The minimal domain of adipose triglyceride lipase (ATGL) ranges until leucine 254 and can be activated and inhibited by CGI-58 and G0S2, respectively. PloS One6, e26349. [PMC free article][PubMed]

13. Egan J. J., Greenberg A. S., Chang M. K., Wek S. A., Moos M. C. Jr., and Londos C. (1992) Mechanism of hormone-stimulated lipolysis in adipocytes: translocation of hormone-sensitive lipase to the lipid storage droplet. Proc. Natl. Acad. Sci. U.S.A. 89, 8537–8541 [PMC free article][PubMed]

14. Ellong E. N., Soni K. G., Bui Q. T., Sougrat R., Golinelli-Cohen M. P., and Jackson C. L. (2011) Interaction between the triglyceride lipase ATGL and the Arf1 activator GBF1. PloS One6, e21889. [PMC free article][PubMed]

15. Gruber A., Cornaciu I., Lass A., Schweiger M., Poeschl M., Eder C., Kumari M., Schoiswohl G., Wolinski H., Kohlwein S. D., Zechner R., Zimmermann R., and Oberer M. (2010) The N-terminal region of comparative gene identification-58 (CGI-58) is important for lipid droplet binding and activation of adipose triglyceride lipase. J. Biol. Chem. 285, 12289–12298 [PMC free article][PubMed]

16. Hofer P., Boeszoermenyi A., Jaeger D., Feiler U., Arthanari H., Mayer N., Zehender F., Rechberger G., Oberer M., Zimmermann R., Lass A., Haemmerle G., Breinbauer R., Zechner R., and Preiss-Landl K. (2015) Fatty acid-binding proteins interact with comparative gene identification-58 linking lipolysis with lipid ligand shuttling. J. Biol. Chem. 290, 18438–18453 [PMC free article][PubMed]

17. Nagy H. M., Paar M., Heier C., Moustafa T., Hofer P., Haemmerle G., Lass A., Zechner R., Oberer M., and Zimmermann R. (2014) Adipose triglyceride lipase activity is inhibited by long-chain acyl-coenzyme A. Biochim. Biophys. Acta1841, 588–594 [PMC free article][PubMed]

18. Sahu-Osen A., Montero-Moran G., Schittmayer M., Fritz K., Dinh A., Chang Y. F., McMahon D., Boeszoermenyi A., Cornaciu I., Russell D., Oberer M., Carman G. M., Birner-Gruenberger R., and Brasaemle D. L. (2015) CGI-58/ABHD5 is phosphorylated on Ser239 by protein kinase A: control of subcellular localization. J. Lipid Res. 56, 109–121 [PMC free article][PubMed]

19. Schweiger M., Paar M., Eder C., Brandis J., Moser E., Gorkiewicz G., Grond S., Radner F. P., Cerk I., Cornaciu I., Oberer M., Kersten S., Zechner R., Zimmermann R., and Lass A. (2012) G0/G1 switch gene-2 regulates human adipocyte lipolysis by affecting activity and localization of adipose triglyceride lipase. J. Lipid Res. 53, 2307–2317 [PMC free article][PubMed]

20. Subramanian V., Rothenberg A., Gomez C., Cohen A. W., Garcia A., Bhattacharyya S., Shapiro L., Dolios G., Wang R., Lisanti M. P., and Brasaemle D. L. (2004) Perilipin A mediates the reversible binding of CGI-58 to lipid droplets in 3T3-L1 adipocytes. J. Biol. Chem. 279, 42062–42071 [PubMed]

21. Sztalryd C., Xu G., Dorward H., Tansey J. T., Contreras J. A., Kimmel A. R., and Londos C. (2003) Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation. J. Cell Biol. 161, 1093–1103 [PMC free article][PubMed]

22. Wang H., Bell M., Sreenivasan U., Sreenevasan U., Hu H., Liu J., Dalen K., Londos C., Yamaguchi T., Rizzo M. A., Coleman R., Gong D., Brasaemle D., and Sztalryd C. (2011) Unique regulation of adipose triglyceride lipase (ATGL) by perilipin 5, a lipid droplet-associated protein. J. Biol. Chem. 286, 15707–15715 [PMC free article][PubMed]

23. Yang X., Lu X., Lombès M., Rha G. B., Chi Y. I., Guerin T. M., Smart E. J., and Liu J. (2010) The G0/G1 switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase. Cell Metab. 11, 194–205 [PMC free article][PubMed]

24. Soni K. G., Mardones G. A., Sougrat R., Smirnova E., Jackson C. L., and Bonifacino J. S. (2009) Coatomer-dependent protein delivery to lipid droplets. J. Cell Sci. 122, 1834–1841 [PMC free article]




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1. “Planning is needed, firstly for committing and allocating the organisation’s limited resources towards achieving

its objectives in the possible manner and, secondly for anticipating th

e future opportunities and problems.”

Elaborate this statement and discuss the underlying concepts as you have experienced in organisational situation. Briefly describe the context, you are referring to. 2. Briefly referring to various models of Decision making process, explain the one/s you have experienced to be favourite in any organisational situation and why. Explain with context, and brief of the organization, you are referring to. 3. What are the major forces for change that confront an organisation? Briefly describe the process of organisational change, and relate it to the experience you have had, or you are aware of. Briefly explain the context and the organisation you are referring to.

4. “The term centralization and decentralization are meaningful only in a relative sense. Centralisation and

decentralisation are extensions of delegation. Delegation refers mainly to entrustment of responsibility and authority from one person to another. Downward transfer of responsibility and authority at individual level is referred to as delegation and when the same is done organisation-wide in a systematic way it is known as


Elaborate this statement and discuss the underlying concepts with reference to the organisational experience your have or are aware of. Please give a brief of the organisation and the context you are referring to.



1. Explain the process of job analysis. Describe how job analysis is carried out in the organisation you are working with or an organisation you are familiar with. 2. Discuss the concept of mentoring. Explain methods of mentoring that you are familiar with citing suitable organisational examples. 3. Discuss in detail the laws covering wages, welfare and benefits. 4. Describe industrial democracy in your own words with illustration.


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